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KMID : 1035520140020010036
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Brain Tumor Research and Treatment : BTRT
2014 Volume.2 No. 1 p.36 ~ p.38
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Glioblastoma in a Patient with Neurofibromatosis Type 1: A Case Report and Review of the Literature
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Jeong Tae-Seok
Yee Gi-Taek
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Abstract
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Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited familial tumor syndrome. Benign tumors such as pilocytic astrocytoma, optic glioma make up the majority of intracranial neoplasms in patients with NF1. There have only been a handful of cases in which adult glioblastoma presented with NF1. A 32-year-old male presented with headache and radiological studies showing a high grade intra-axial tumor. The patient underwent gross total surgical excision and the pathology revealed glioblastoma. After the surgery, he received concomitant chemo-radiotherapy with temozolomide and adjuvant temozolomide chemotherapy. We report a NF1 patient who developed glioblastoma and reviewed related articles.
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KEYWORD
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Glioblastoma, Neurofibromatosis type 1, CCRT, Temozolomide
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